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Persistence and clearance of human papillomavirus infection: a prospective cohort study

LIDIA R. MEDEIROS, DANIELA DORNELLES ROSA, JANDIRA M. G. FACHEL, MARY C. BOZZETTI, MARIA INÊS ROSA, CRISTINE N. IGANSI

American Journal of Obstetrics & Gynecology, v. 199, n. 0, p. 1-7, 2008.

Motivo: Professor IEP

Setor HMV: Nucleo Mama Moinhos

Área da saúde:

Resumo: OBJECTIVE: The objective of the study was to identify epidemiological correlates for persistence and clearance of human papillomavirus (HPV) infection. STUDY DESIGN: Cervical smears collected in a prospective cohort study to perform Papanicoloau cytology and HPV eoxyribonucleic acid (DNA) detection at baseline and during the follow-up. Outcomes analyzed were: (1) persistence of HPV DNA; (2) conversion; and (3) clearance of HPV. RESULTS: Among 501 women the incidence of HPV was 12.3%. Thirty-four women were persistently infected with HPV, which was associated with age below 21 years at first intercourse and 4 or more sexual partners during their lifetime. In a median of 19 months, 80.7% of women had clearance of HPV, which was associated with black race, coinfection with Chlamydia trachomatis at baseline, and a history of previous Papanicoloau smear. CONCLUSION: Strategies for sexual orientation may modify the rates of HPV persistence. The association of HPV clearance with a history of previous Papanicolaou smear screening highlights the importance of improving cervical screening programs. Further studies on the association of gynecological infections with HPV clearance are needed.

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