Artigo

Importance of prostate-specific antigen (PSA) as a predictive factor for concordance between the Gleason scores of prostate biopsies and radical prostatectomy specimens

NELSON GIANNI DE LIMA, DANIEL DE FREITAS GOMES SOARES, ERNANI LUIS RHODEN

Clinics, v. 68, n. 6, p. 820-824, 2013.

Motivo: Produção Corpo Clínico

Setor HMV: Urologia

Área da saúde: Urologia

Resumo: OBJECTIVE: To evaluate the concordance between the Gleason scores of prostate biopsies and radical prostatectomy specimens, thereby highlighting the importance of the prostate-specific antigen (PSA) level as a predictive factor of concordance. METHODS: We retrospectively analyzed 253 radical prostatectomy cases performed between 2006 and 2011. The patients were divided into 4 groups for the data analysis and dichotomized according to the preoperative PSA, ,10 ng/mL and $10 ng/mL. A p-score ,0.05 was considered significant. RESULTS: The average patient age was 63.3¡7.8 years. The median PSA level was 9.3¡4.9 ng/mL. The overall concordance between the Gleason scores was 52%. Patients presented preoperative PSA levels ,10 ng/mL in 153 of 235 cases (65%) and $10 ng/mL in 82 of 235 cases (35%). The Gleason scores were identical in 86 of 153 cases (56%) in the ,10 ng/mL group and 36 of 82 (44%) cases in the $10 ng/mL group (p = 0.017). The biopsy underestimated the Gleason score in 45 (30%) patients in the ,10 ng/mL group and 38 (46%) patients in the $10 ng/mL (p = 0.243). Specifically, the patients with Gleason 3 + 3 scores according to the biopsies demonstrated global concordance in 56 of 110 cases (51%). In this group, the patients with preoperative PSA levels ,10 ng/dL had higher concordance than those with preoperative PSA levels $10 ng/dL (61% x 23%, p = 0.023), which resulted in 77% upgrading after surgery in those patients with PSA levels $10 ng/dl. CONCLUSION: The Gleason scores of needle prostate biopsies and those of the surgical specimens were concordant in approximately half of the global sample. The preoperative PSA level was a strong predictor of discrepancy and might improve the identification of those patients who tended to be upgraded after surgery, particularly in patients with Gleason scores of 3 + 3 in the prostate biopsy and preoperative PSA levels $10 ng/ mL.

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