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Characteristics of tumors detected by screen-film and digital mammography during breast cancer screening

ADEMAR JOSE BEDIN JUNIOR, DAKIR LOURENCO DUARTE FILHO, LUIS ANTONIO ABREU DE MORAES NETO, Clarissa M. Ferreira, RODRIGO ANTONINI RIBEIRO, DANIELA DORNELLES ROSA, MAIRA CALEFFI, ELIANA MARCIA DA ROS WENDLAND

Em: ASCO Annual Meeting, 2014, v. 32, n. suppl, p. 0-0.

Motivo: Produção Colaborador HMV

Setor HMV: Nucleo Mama POA

Área da saúde: Oncologia

Resumo: Background: Screening mammography is the single most effective method of breas cancer (BC) detection, and the introduction of full-field digital mammography (FFDM) was suggested to be superior to screen-film mammography (SFM) to detect BC in early stages. Therefore, the aim to this study was to describe the clinical characteristics of patients with BC diagnosed at a screening cohort in southern Brazil, according with the type of mammography (FFDM or SFM). Methods: After accrual period, women from 40 to 69 years old were followed annually through clinical examination and mammograms. Clinical and immunohistochemical characteristics were evaluated according to the type of mammography performed: SFM (2006-2010) and FFDM (2011-2013). All mammograms were interpreted by the same radiologist. Complementary diagnostic procedures were done in the same screening day as needed and surgical treatment was performing on study site. The e² or Fisher test were used to compare categories and t-test was used to compare means. Results: From circa 2,800 women, 41 cases of invasive BC were detected from 2006 to 2013. Although the overall incidence of BC did not change after digital transition, an increase was observed in women from 40-49 years old (from 45.8 to 184.4/1000,000; p<0.01) and a decrease in women 50-69 years old with a non-significant tendency of lower mean age in the FFDM period (52.7 vc 57.2; p=0.07). There was no differences in the proportion of women in advanced stages, tumor size and histological grade according with mammogram type. A higher proportion of women had positive progesterone receptor in the FFDM period (p=0.03). There were no differences in Cerb2, p53, ki-67 and estrogen receptors. All BC detected after digital transition were ductal invasive carcicomas (versus 76.9% in SFM period). Conclusions: The use of FFDM increases the detection of breast cancer in young women but the transition to FFDM did not modify tumor clinical and immunohitochemical characteristics.

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